Reaction Details | |||
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Target | Adenosine receptor A2a | ||
Ligand | BDBM522454 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | HTRF Assay | ||
Ki | <10±n/a nM | ||
Citation | Wang, X; Li, Y; Qi, C; Wu, L; Yao, W; Zhu, W Fused pyrazine derivatives as A2A / A2B inhibitors US Patent US11161850 Publication Date 11/2/2021 | ||
More Info.: | Get all data from this article, Assay Method | ||
Adenosine receptor A2a | |||
Name: | Adenosine receptor A2a | ||
Synonyms: | A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR) | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 44716.46 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P29274 | ||
Residue: | 412 | ||
Sequence: |
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BDBM522454 | |||
n/a | |||
Name | BDBM522454 | ||
Synonyms: | US11161850, Example 1 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H20N8O | ||
Mol. Mass. | 400.4365 | ||
SMILES | CCNC(=O)c1cc2c(N)nc(-c3cccc(c3)C#N)c(-c3ccnn3CC)n2n1 |(8.16,-3.85,;7.39,-2.52,;5.85,-2.52,;5.08,-1.18,;5.85,.15,;3.54,-1.18,;2.64,-2.43,;1.17,-1.95,;-.16,-2.72,;-.16,-4.26,;-1.49,-1.95,;-1.49,-.41,;-2.83,.36,;-2.83,1.9,;-4.16,2.67,;-5.5,1.9,;-5.5,.36,;-4.16,-.41,;-6.83,-.41,;-8.16,-1.18,;-.16,.36,;-.16,1.9,;-1.41,2.8,;-.93,4.26,;.61,4.26,;1.09,2.8,;2.57,2.4,;3.66,3.49,;1.17,-.41,;2.64,.06,)| | ||
Structure |