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TargetAdenosine receptor A2a
LigandBDBM522720
Substrate/Competitorn/a
Meas. Tech.HTRF Assay
Ki<10±n/a nM
Citation Wang, XLi, YQi, CWu, LYao, WZhu, W Fused pyrazine derivatives as A2A / A2B inhibitors US Patent US11161850 Publication Date 11/2/2021
More Info.:Get all data from this article,  Assay Method
 
Adenosine receptor A2a
Name:Adenosine receptor A2a
Synonyms:A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:44716.46
Organism:Homo sapiens (Human)
Description:P29274
Residue:412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
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  Blast E-value cutoff:
BDBM522720
n/a
NameBDBM522720
Synonyms:US11161850, Example 78
TypeSmall organic molecule
Emp. Form.C24H18F2N8O
Mol. Mass.472.4495
SMILESCNC(c1nc2c(N)nc(-c3cccc(c3)C#N)c(-c3ocnc3C)n2n1)c1c(F)cccc1F |(7.39,-2.52,;5.85,-2.52,;5.08,-1.18,;3.54,-1.18,;2.64,-2.43,;1.17,-1.95,;-.16,-2.72,;-.16,-4.26,;-1.49,-1.95,;-1.49,-.41,;-2.83,.36,;-2.83,1.9,;-4.16,2.67,;-5.5,1.9,;-5.5,.36,;-4.16,-.41,;-6.83,-.41,;-8.16,-1.18,;-.16,.36,;-.16,1.9,;-1.41,2.8,;-.93,4.26,;.61,4.26,;1.09,2.8,;2.55,2.32,;1.17,-.41,;2.64,.06,;5.85,.15,;7.39,.15,;8.16,-1.18,;8.16,1.48,;7.39,2.82,;5.85,2.82,;5.08,1.48,;3.54,1.48,)|
Structure
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