| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Nek7 |
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| Ligand | BDBM522972 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Assay |
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| IC50 | 1000±n/a nM |
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| Citation |  Bearss, DJ; Kauwe, III, JS; Mollard, AH Inhibitors of NEK7 kinase US Patent US11161852 Publication Date 11/2/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Nek7 |
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| Name: | Serine/threonine-protein kinase Nek7 |
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| Synonyms: | NEK kinase | NEK7 | NEK7_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34559.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_586832 |
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| Residue: | 302 |
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| Sequence: | MDEQSQGMQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPV
ALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLS
RMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDL
GLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDK
MNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKRMHACTA
SS
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| BDBM522972 |
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| n/a |
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| Name | BDBM522972 |
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| Synonyms: | 1-(4-(4-amino-7- cyclopropyl-7H- pyrrolo[2,3- d]pyrimidin-5-yl)-2- fluorophenyl)-3-(3- methylisoxazol-5- yl)urea | US11161852, Compound 7 | US11713321, Example 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18FN7O2 |
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| Mol. Mass. | 407.401 |
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| SMILES | Cc1cc(NC(=O)Nc2ccc(cc2F)-c2cn(C3CC3)c3ncnc(N)c23)on1 |
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| Structure | 
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