| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Nek7 |
|---|
| Ligand | BDBM523019 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzymatic Assay |
|---|
| IC50 | 400±n/a nM |
|---|
| Citation |  Bearss, DJ; Kauwe, III, JS; Mollard, AH Inhibitors of NEK7 kinase US Patent US11161852 Publication Date 11/2/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase Nek7 |
|---|
| Name: | Serine/threonine-protein kinase Nek7 |
|---|
| Synonyms: | NEK kinase | NEK7 | NEK7_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 34559.15 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_586832 |
|---|
| Residue: | 302 |
|---|
| Sequence: | MDEQSQGMQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPV
ALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLS
RMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDL
GLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDK
MNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKRMHACTA
SS
|
|
|
|---|
| BDBM523019 |
|---|
| n/a |
|---|
| Name | BDBM523019 |
|---|
| Synonyms: | 1-(4-(4-amino-7- cyclobutyl-7H- pyrrolo[2,3- d]pyrimidin-5-yl)-2- fluorophenyl)-3-(3-(1- (trifluoromethyl)cyclopropyl)isoxazol- 5-yl)urea | US11161852, Compound 53 | US11713321, Example 53 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H21F4N7O2 |
|---|
| Mol. Mass. | 515.4629 |
|---|
| SMILES | Nc1ncnc2n(cc(-c3ccc(NC(=O)Nc4cc(no4)C4(CC4)C(F)(F)F)c(F)c3)c12)C1CCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
