| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sphingolipid delta(4)-desaturase DES1 |
|---|
| Ligand | BDBM523256 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Des1 Activity Assays |
|---|
| IC50 | 19.0±n/a nM |
|---|
| Citation |  Romero, DL; McCall, JM; Blitzer, J Inhibitors of dihydroceramide desaturase for treating disease US Patent US11135207 Publication Date 10/5/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sphingolipid delta(4)-desaturase DES1 |
|---|
| Name: | Sphingolipid delta(4)-desaturase DES1 |
|---|
| Synonyms: | Cell migration-inducing gene 15 protein | DEGS1 | DEGS1_HUMAN | DES1 | Degenerative spermatocyte homolog 1 | MLD | Membrane lipid desaturase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 37872.63 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_816893 |
|---|
| Residue: | 323 |
|---|
| Sequence: | MGSRVSREDFEWVYTDQPHADRRREILAKYPEIKSLMKPDPNLIWIIIMMVLTQLGAFYI
VKDLDWKWVIFGAYAFGSCINHSMTLAIHEIAHNAAFGNCKAMWNRWFGMFANLPIGIPY
SISFKRYHMDHHRYLGADGVDVDIPTDFEGWFFCTAFRKFIWVILQPLFYAFRPLFINPK
PITYLEVINTVAQVTFDILIYYFLGIKSLVYMLAASLLGLGLHPISGHFIAEHYMFLKGH
ETYSYYGPLNLLTFNVGYHNEHHDFPNIPGKSLPLVRKIAAEYYDNLPHYNSWIKVLYDF
VMDDTISPYSRMKRHQKGEMVLE
|
|
|
|---|
| BDBM523256 |
|---|
| n/a |
|---|
| Name | BDBM523256 |
|---|
| Synonyms: | 2'-chloro-N- (5-hydroxy- pyridin-2-yl)- [1,1'- biphenyl]-4- carboxamide | US11135207, Example 38 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H13ClN2O2 |
|---|
| Mol. Mass. | 324.761 |
|---|
| SMILES | Oc1ccc(NC(=O)c2ccc(cc2)-c2ccccc2Cl)nc1 |
|---|
| Structure | 
|
|---|
Search and Browse
