| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingolipid delta(4)-desaturase DES1 |
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| Ligand | BDBM523270 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Des1 Activity Assays |
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| IC50 | 3.90±n/a nM |
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| Citation |  Romero, DL; McCall, JM; Blitzer, J Inhibitors of dihydroceramide desaturase for treating disease US Patent US11135207 Publication Date 10/5/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingolipid delta(4)-desaturase DES1 |
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| Name: | Sphingolipid delta(4)-desaturase DES1 |
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| Synonyms: | Cell migration-inducing gene 15 protein | DEGS1 | DEGS1_HUMAN | DES1 | Degenerative spermatocyte homolog 1 | MLD | Membrane lipid desaturase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 37872.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_816893 |
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| Residue: | 323 |
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| Sequence: | MGSRVSREDFEWVYTDQPHADRRREILAKYPEIKSLMKPDPNLIWIIIMMVLTQLGAFYI
VKDLDWKWVIFGAYAFGSCINHSMTLAIHEIAHNAAFGNCKAMWNRWFGMFANLPIGIPY
SISFKRYHMDHHRYLGADGVDVDIPTDFEGWFFCTAFRKFIWVILQPLFYAFRPLFINPK
PITYLEVINTVAQVTFDILIYYFLGIKSLVYMLAASLLGLGLHPISGHFIAEHYMFLKGH
ETYSYYGPLNLLTFNVGYHNEHHDFPNIPGKSLPLVRKIAAEYYDNLPHYNSWIKVLYDF
VMDDTISPYSRMKRHQKGEMVLE
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| BDBM523270 |
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| n/a |
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| Name | BDBM523270 |
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| Synonyms: | 2-[1-(5-chloropyridin-2-yl)piperidin-4-yl]-N-(5-hydroxypyridin-2-yl) acetamide | US11135207, Example 57 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19ClN4O2 |
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| Mol. Mass. | 346.811 |
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| SMILES | Oc1ccc(NC(=O)CC2CCN(CC2)c2ccc(Cl)cn2)nc1 |
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| Structure | 
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