| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit |
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| Ligand | BDBM524078 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Pharmacological Activity |
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| IC50 | 1.40±n/a nM |
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| Citation |  Trieselmann, T; Godbout, C; Vintonyak, V Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors US Patent US11136337 Publication Date 10/5/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit |
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| Name: | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit |
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| Synonyms: | O-GlcNAc Transferase (OGT) | O-GlcNAc transferase subunit p110 | O-linked N-acetylglucosamine transferase 110 kDa subunit | OGT | OGT1_HUMAN | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit |
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| Type: | Protein |
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| Mol. Mass.: | 116927.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O15294 |
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| Residue: | 1046 |
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| Sequence: | MASSVGNVADSTEPTKRMLSFQGLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLL
LSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKP
DFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACY
LKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARI
FDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLA
NALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEF
AAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTR
AIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWT
DYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHK
PPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFCYALSPDDGTN
FRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQA
MWLGYPGTSGALFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAV
IDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKCPDGGDNADSSNTALNMPVIPMN
TIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPED
AIVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRI
IFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQL
TCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLY
LQMWEHYAAGNKPDHMIKPVEVTESA
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|
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| BDBM524078 |
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| n/a |
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| Name | BDBM524078 |
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| Synonyms: | US11136337, Example 1.8 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H9F3N6O |
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| Mol. Mass. | 298.224 |
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| SMILES | Cc1nc2nonc2c(N)c1Cn1cc(cn1)C(F)(F)F |
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| Structure | 
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