| Reaction Details |
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 | Report a problem with these data |
| Target | Angiotensin-converting enzyme/Ribosomal RNA small subunit methyltransferase NEP1 |
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| Ligand | BDBM471712 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| Ki | <1.000±n/a nM |
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| Citation |  Fleury, M; Hughes, AD Neprilysin inhibitors US Patent US11174219 Publication Date 11/16/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Angiotensin-converting enzyme/Ribosomal RNA small subunit methyltransferase NEP1 |
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| Name: | Angiotensin-converting enzyme/Ribosomal RNA small subunit methyltransferase NEP1 |
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| Synonyms: | Recombinant human NEP and recombinant human ACE |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Ribosomal RNA small subunit methyltransferase NEP1 |
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| Synonyms: | 18S rRNA (pseudouridine(1248)-N1)-methyltransferase | 18S rRNA Psi1248 methyltransferase | C2F | EMG1 | NEP1_HUMAN | Nucleolar protein EMG1 homolog | Protein C2f | Ribosome biogenesis protein NEP1 |
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| Type: | Protein |
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| Mol. Mass.: | 26729.88 |
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| Organism: | Human |
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| Description: | Q92979 |
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| Residue: | 244 |
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| Sequence: | MAAPSDGFKPRERSGGEQAQDWDALPPKRPRLGAGNKIGGRRLIVVLEGASLETVKVGKT
YELLNCDKHKSILLKNGRDPGEARPDITHQSLLMLMDSPLNRAGLLQVYIHTQKNVLIEV
NPQTRIPRTFDRFCGLMVQLLHKLSVRAADGPQKLLKVIKNPVSDHFPVGCMKVGTSFSI
PVVSDVRELVPSSDPIVFVVGAFAHGKVSVEYTEKMVSISNYPLSAALTCAKLTTAFEEV
WGVI
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| Component 2 |
| Name: | Angiotensin-converting enzyme |
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| Synonyms: | ACE | ACE_HUMAN | Angiotensin converting enzyme (ACE) | Angiotensin-converting enzyme, ACE | Angiotensin-converting enzyme, soluble form | Angiotensin-converting enzyme, somatic isoform | CD_antigen=CD143 | DCP | DCP1 | Dipeptidyl carboxypeptidase I | Kininase II |
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| Type: | Enzyme |
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| Mol. Mass.: | 149709.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 1306 |
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| Sequence: | MGAASGRRGPGLLLPLPLLLLLPPQPALALDPGLQPGNFSADEAGAQLFAQSYNSSAEQV
LFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQNFTDPQLRRI
IGAVRTLGSANLPLAKRQQYNALLSNMSRIYSTAKVCLPNKTATCWSLDPDLTNILASSR
SYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFEDDL
EHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPF
PDKPNLDVTSTMLQQGWNATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCH
ASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAI
GDVLALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFS
GRTPPSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQF
HEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLQAGSSRPWQEVLKDMVGLDALDAQPLL
KYFQPVTQWLQEQNQQNGEVLGWPEYQWHPPLPDNYPEGIDLVTDEAEASKFVEEYDRTS
QVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRI
IKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPNGSCLQLEPDLTNVMATSRKY
EDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLER
LFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVVPFPS
APSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHAS
AWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGD
VLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGS
ITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHE
ALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSY
FKPLLDWLRTENELHGEKLGWPQYNWTPNSARSEGPLPDSGRVSFLGLDLDAQQARVGQW
LLLFLGIALLVATLGLSQRLFSIRHRSLHRHSHGPQFGSEVELRHS
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| BDBM471712 |
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| n/a |
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| Name | BDBM471712 |
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| Synonyms: | US10829438, Example 4B | US11174219, Example 4B |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25ClFN3O5 |
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| Mol. Mass. | 501.935 |
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| SMILES | CCOC(=O)[C@H](O)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cc([nH]n1)C(C)=O |r| |
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| Structure | 
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