| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [695-1022] |
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| Ligand | BDBM525446 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical EGFR Inhibition Assays (100 mM ATP) |
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| IC50 | 217±n/a nM |
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| Citation |  Boese, D; Dahmann, G; Engelhardt, H; Petronczki, M; Scharn, D Benzimidazole compounds and derivatives as EGFR inhibitors US Patent US11174245 Publication Date 11/16/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Epidermal growth factor receptor [695-1022] |
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| Name: | Epidermal growth factor receptor [695-1022] |
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| Synonyms: | EGFR | EGFR (aa 695-1022) | EGFR_HUMAN | ERBB | ERBB1 | HER1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 37339.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00533[695-1022] |
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| Residue: | 328 |
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| Sequence: | SGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPK
ANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYL
LNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGG
KVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLP
QPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTD
SNFYRALMDEEDMDDVVDADEYLIPQQG
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| BDBM525446 |
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| n/a |
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| Name | BDBM525446 |
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| Synonyms: | US11174245, # I-031 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H34N6O4 |
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| Mol. Mass. | 542.6288 |
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| SMILES | COc1ccncc1-c1cc(ccn1)C(=O)\N=c1/[nH]c2cc(ccc2n1CC(C)(C)O)C1CCN(CC1)C(C)=O |
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| Structure | 
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