Ki Summary

Reaction Details

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Target

Epidermal growth factor receptor [695-1022,T790M,C797S,L858R]

Ligand

BDBM525486

Substrate/Competitor

n/a

Meas. Tech.

Biochemical EGFR Inhibition Assays (5 mM ATP)

IC50

0.800±n/a nM

Citation

Boese, D; Dahmann, G; Engelhardt, H; Petronczki, M; Scharn, D Benzimidazole compounds and derivatives as EGFR inhibitors US Patent US11174245 Publication Date 11/16/2021

More Info.:

Get all data from this article, Assay Method

Epidermal growth factor receptor [695-1022,T790M,C797S,L858R]

Name:

Epidermal growth factor receptor [695-1022,T790M,C797S,L858R]

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

37397.86

Organism:

Homo sapiens (Human)

Description:

P00533[695-1022,T790M,C797S,L858R]

Residue:

328

Sequence:

SGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPK
ANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYL
LNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGG
KVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLP
QPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTD
SNFYRALMDEEDMDDVVDADEYLIPQQG

BDBM525486

n/a

Name

BDBM525486

Synonyms:

US11174245, # I-136 | US11174245, # I-138

Type

Small organic molecule

Emp. Form.

C24H23N7O2

Mol. Mass.

441.4851

SMILES

Cn1cc(cn1)-c1cc(cc(n1)C#N)C(=O)\N=c1/[nH]c2ccccc2n1[C@@H]1CC[C@H](O)CC1 |r,wU:26.29,29.33,(5.75,-4.31,;5.75,-2.77,;4.5,-1.87,;4.98,-.4,;6.52,-.4,;6.99,-1.87,;4.21,.93,;2.67,.93,;1.9,2.26,;2.67,3.6,;4.21,3.6,;4.98,2.26,;4.98,4.93,;5.75,6.27,;.36,2.26,;-.41,3.6,;-.41,.93,;-1.95,.93,;-2.86,2.18,;-4.32,1.7,;-5.66,2.47,;-6.99,1.7,;-6.99,.16,;-5.66,-.61,;-4.32,.16,;-2.86,-.32,;-2.46,-1.8,;-3.55,-2.89,;-3.15,-4.38,;-1.66,-4.78,;-1.27,-6.27,;-.57,-3.69,;-.97,-2.2,)|

Structure