| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Epidermal growth factor receptor [695-1022] |
|---|
| Ligand | BDBM525495 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical EGFR Inhibition Assays (5 mM ATP) |
|---|
| IC50 | 77.8±n/a nM |
|---|
| Citation |  Boese, D; Dahmann, G; Engelhardt, H; Petronczki, M; Scharn, D Benzimidazole compounds and derivatives as EGFR inhibitors US Patent US11174245 Publication Date 11/16/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Epidermal growth factor receptor [695-1022] |
|---|
| Name: | Epidermal growth factor receptor [695-1022] |
|---|
| Synonyms: | EGFR | EGFR (aa 695-1022) | EGFR_HUMAN | ERBB | ERBB1 | HER1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 37339.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00533[695-1022] |
|---|
| Residue: | 328 |
|---|
| Sequence: | SGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPK
ANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYL
LNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGG
KVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLP
QPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTD
SNFYRALMDEEDMDDVVDADEYLIPQQG
|
|
|
|---|
| BDBM525495 |
|---|
| n/a |
|---|
| Name | BDBM525495 |
|---|
| Synonyms: | US11174245, # I-148 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H35N5O4 |
|---|
| Mol. Mass. | 541.6407 |
|---|
| SMILES | COc1ccccc1-c1cc(ccn1)C(=O)\N=c1/[nH]c2cc(CN3CCOCC3)ccc2n1[C@H]1CCC[C@@H](O)C1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
