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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Epidermal growth factor receptor [695-1022] | ||
| Ligand | BDBM525525 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Biochemical EGFR Inhibition Assays (5 mM ATP) | ||
| IC50 | 179±n/a nM | ||
| Citation |  Boese, D; Dahmann, G; Engelhardt, H; Petronczki, M; Scharn, D Benzimidazole compounds and derivatives as EGFR inhibitors US Patent US11174245 Publication Date 11/16/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Epidermal growth factor receptor [695-1022] | |||
| Name: | Epidermal growth factor receptor [695-1022] | ||
| Synonyms: | EGFR | EGFR (aa 695-1022) | EGFR_HUMAN | ERBB | ERBB1 | HER1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 37339.79 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P00533[695-1022] | ||
| Residue: | 328 | ||
| Sequence: |
| ||
| BDBM525525 | |||
| n/a | |||
| Name | BDBM525525 | ||
| Synonyms: | US11174245, # I-203 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H23ClN6O2 | ||
| Mol. Mass. | 450.921 | ||
| SMILES | Cn1ncc(c1Cl)-c1cc(ccn1)C(=O)\N=c1/[nH]c2ccccc2n1[C@@H]1CC[C@H](O)CC1 |r,wU:25.28,28.32,(5.75,-2.98,;5.75,-1.44,;6.99,-.53,;6.52,.93,;4.98,.93,;4.5,-.53,;3.17,-1.3,;4.21,2.26,;2.67,2.26,;1.9,3.6,;2.67,4.93,;4.21,4.93,;4.98,3.6,;.36,3.6,;-.41,4.93,;-.41,2.26,;-1.95,2.26,;-2.86,3.51,;-4.32,3.03,;-5.66,3.8,;-6.99,3.03,;-6.99,1.49,;-5.66,.72,;-4.32,1.49,;-2.86,1.02,;-2.46,-.47,;-3.55,-1.56,;-3.15,-3.05,;-1.66,-3.44,;-1.27,-4.93,;-.57,-2.36,;-.97,-.87,)| | ||
| Structure | 
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