Reaction Details |
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Target | Epidermal growth factor receptor [695-745,751-1022,T790M,C797S] |
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Ligand | BDBM525542 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biochemical EGFR Inhibition Assays (5 mM ATP) |
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IC50 | 2.00±n/a nM |
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Citation | Boese, D; Dahmann, G; Engelhardt, H; Petronczki, M; Scharn, D Benzimidazole compounds and derivatives as EGFR inhibitors US Patent US11174245 Publication Date 11/16/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Epidermal growth factor receptor [695-745,751-1022,T790M,C797S] |
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Name: | Epidermal growth factor receptor [695-745,751-1022,T790M,C797S] |
Synonyms: | EGFR | EGFR (aa 895-745, aa 751-1022, T790M, C797S) | EGFR_HUMAN | ERBB | ERBB1 | HER1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 36756.18 |
Organism: | Homo sapiens (Human) |
Description: | P00533[695-745,751-1022,T790M,C797S] |
Residue: | 323 |
Sequence: | SGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEI
LDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCV
QIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIK
WMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPIC
TIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYR
ALMDEEDMDDVVDADEYLIPQQG
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BDBM525542 |
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n/a |
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Name | BDBM525542 |
Synonyms: | US11174245, # I-220 |
Type | Small organic molecule |
Emp. Form. | C22H22N6O2S |
Mol. Mass. | 434.514 |
SMILES | Cn1cc(cn1)-c1cc(ccn1)C(=O)\N=c1/[nH]c2ccccc2n1C1CCCS(=O)C1 |
Structure |
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