| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4 |
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| Ligand | BDBM525743 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Kinase Inhibition Assay |
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| IC50 | 1.50±n/a nM |
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| Citation |  Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J Heterocyclic compounds as kinase inhibitors US Patent US11174252 Publication Date 11/16/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 4 |
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| Name: | Cyclin-dependent kinase 4 |
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| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33731.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11802 |
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| Residue: | 303 |
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| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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| BDBM525743 |
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| n/a |
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| Name | BDBM525743 |
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| Synonyms: | US11174252, Compound 38 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H33F2N7O |
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| Mol. Mass. | 509.594 |
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| SMILES | CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(nc2)N2CCC(CC2)N(C)C)ncc1F |
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| Structure | 
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