| Reaction Details |
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 | Report a problem with these data |
| Target | PAS domain-containing serine/threonine-protein kinase |
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| Ligand | BDBM528485 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radiochemical Assay |
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| IC50 | <10000±n/a nM |
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| Citation |  McCall, J; Kelly, RC; Romero, DL Heterocyclic compounds for the inhibition of PASK US Patent US11191765 Publication Date 12/7/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| PAS domain-containing serine/threonine-protein kinase |
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| Name: | PAS domain-containing serine/threonine-protein kinase |
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| Synonyms: | KIAA0135 | PAS-kinase | PASK | PASKIN | PASK_HUMAN | hPASK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 142867.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_944230 |
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| Residue: | 1323 |
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| Sequence: | MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT
DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEE
NPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQPVNLADY
TWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCLHPGDPRL
LTS
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| BDBM528485 |
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| n/a |
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| Name | BDBM528485 |
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| Synonyms: | 5-(3,4-Dimethoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one | US11191765, Example 37 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H12N4O3 |
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| Mol. Mass. | 272.2594 |
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| SMILES | COc1ccc(cc1OC)-c1cc(=O)n2ncnc2[nH]1 |
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| Structure | 
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