Reaction Details |
| Report a problem with these data |
Target | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
---|
Ligand | BDBM304035 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Assay of Phosphodiesterase 10 Inhibition In Vitro |
---|
IC50 | 172±n/a nM |
---|
Citation | Moszczynski-Petkowski, R; Bojarski, L; Wieczorek, M; Majer, J; Janowska, S; Matloka, M; Borkowska, M; Stefaniak, F; Lamparska-Przybysz, M; Dubiel, K Fused triazole derivatives as phosphodiesterase 10A inhibitors US Patent US10138245 Publication Date 11/27/2018 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
---|
Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
Synonyms: | 3',5'-cyclic phosphodiesterase | 3.1.4.17 | PDE10A | PDE10_HUMAN | Phosphodiesterase 10 (PDE10) | Phosphodiesterase 10A |
Type: | Protein |
Mol. Mass.: | 88412.52 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y233 |
Residue: | 1055 |
Sequence: | MASLEEPLAPRPQGPLPAAGDEPGCGPGKLRPEPRLSAAGGGSAAGPGPAPEWPGRGRAE
RAAPPRPPLSSAGRPSPAGGPGALSARGGGCGWVAARAPLALAFSSRVPSSSPSFFYFWP
PPPPPPPSFLPSSSAFHLPVRLPGREGAAAAAAAGGGGDAGGGGGGGQEAAPLSVPTSSS
HRGGGGSGGGRRRLFLSPALQGLLLPARAGPRPPPPPRLPLGQAARRAGSPGFPGAGPGG
GGQTPRRPQGASFALAAAAALLFGSDMEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLS
LHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQ
RLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGP
ITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGIL
ELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNI
VAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRF
SIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQM
VNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSE
EWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMS
VKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSY
LQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATD
LALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYA
EFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKA
CRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
|
|
|
BDBM304035 |
---|
n/a |
---|
Name | BDBM304035 |
Synonyms: | 2-[2-(3-Fluorophenyl)-1H-benzimidazol-5-yl]-5,8-dimethyl[1,2,4]triazolo[1,5-a]pyrazine | US10138245, Example 6 |
Type | Small organic molecule |
Emp. Form. | C20H15FN6 |
Mol. Mass. | 358.3717 |
SMILES | Cc1cnc(C)c2nc(nn12)-c1ccc2[nH]c(nc2c1)-c1cccc(F)c1 |
Structure |
|