Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase receptor UFO

Ligand

BDBM531965

Substrate/Competitor

n/a

Meas. Tech.

Cell-Free Axl Kinase Inhibitory Activity

IC50

1.30±n/a nM

Citation

Haginoya, N; Suzuki, T; Hayakawa, M; Ota, M; Tsukada, T; Kobayashi, K; Ando, Y; Jimbo, T; Nakamura, K Pyridone derivatives having tetrahydropyranylmethyl groups US Patent US11208403 Publication Date 12/28/2021

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase receptor UFO

Name:

Tyrosine-protein kinase receptor UFO

Synonyms:

Type:

Enzyme

Mol. Mass.:

98316.97

Organism:

Homo sapiens (Human)

Description:

P30530

Residue:

894

Sequence:

MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV
QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF
LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL
ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE
LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH
PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL
QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP
VPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR
YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK
TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL
IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM
EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES
LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA
LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA
DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA

BDBM531965

n/a

Name

BDBM531965

Synonyms:

US11208403, Example 42

Type

Small organic molecule

Emp. Form.

C31H31FN4O4

Mol. Mass.

542.6006

SMILES

COc1ccnc(N)c1-c1ccc(NC(=O)c2cn(CC3CCOCC3)cc(-c3ccc(C)cc3)c2=O)cc1F |(9.34,-.77,;8,-1.54,;8,-3.08,;9.34,-3.85,;9.34,-5.39,;8,-6.16,;6.67,-5.39,;5.33,-6.16,;6.67,-3.85,;5.33,-3.08,;4,-3.85,;2.67,-3.08,;2.67,-1.54,;1.33,-.77,;,-1.54,;,-3.08,;-1.33,-.77,;-1.33,.77,;-2.67,1.54,;-2.67,3.08,;-1.33,3.85,;,3.08,;1.33,3.85,;1.33,5.39,;,6.16,;-1.33,5.39,;-4,.77,;-4,-.77,;-5.33,-1.54,;-6.67,-.77,;-8,-1.54,;-8,-3.08,;-9.34,-3.85,;-6.67,-3.85,;-5.33,-3.08,;-2.67,-1.54,;-2.67,-3.08,;4,-.77,;5.33,-1.54,;6.67,-.77,)|

Structure