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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Isoform 1 of Metabotropic glutamate receptor 5 (5a) | ||
| Ligand | BDBM174267 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | mGluR5 FLIPR Assay | ||
| EC50 | >3226±n/a nM | ||
| Citation |  Degnan, AP; Maxwell, D; Hill, MD; Fang, H; Parker, MF; Yang, F; Bronson, JJ; Macor, JE Oxazolidinones as modulators of mGluR5 US Patent US9688669 Publication Date 6/27/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Isoform 1 of Metabotropic glutamate receptor 5 (5a) | |||
| Name: | Isoform 1 of Metabotropic glutamate receptor 5 (5a) | ||
| Synonyms: | GPRC1E | GRM5 | GRM5_HUMAN | MGLUR5 | Metabotropic glutamate receptor 5 | Metabotropic glutamate receptor 5 (5a) | Metabotropic glutamate receptor 5 (mGlu5a) | Metabotropic glutamate receptor 5 (mGluR5a) | Metabotropic glutamate receptor 5a (mGluR5) | Metabotropic glutamate receptor 5a (mGluR5a) | Metabotropic glutamate receptor subtype 5 (mGluR5) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 128885.13 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41594-2 | ||
| Residue: | 1180 | ||
| Sequence: |
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| BDBM174267 | |||
| n/a | |||
| Name | BDBM174267 | ||
| Synonyms: | US9688669, Example 98 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H16F2N2O2 | ||
| Mol. Mass. | 354.35 | ||
| SMILES | F[C@H]1C[C@H](C1)C#Cc1cncc(c1)[C@H]1NC(=O)O[C@@H]1c1cccc(F)c1 |r,wU:13.14,3.5,1.0,wD:18.21,(-7.08,-3.45,;-5.75,-4.22,;-4.26,-3.82,;-3.86,-5.31,;-5.35,-5.71,;-2.53,-6.08,;-1.2,-6.85,;.14,-7.62,;.14,-9.16,;1.47,-9.93,;2.8,-9.16,;2.8,-7.62,;1.47,-6.85,;4.14,-6.85,;4.14,-5.31,;5.6,-4.83,;6.37,-3.5,;6.51,-6.08,;5.6,-7.33,;6,-8.81,;7.49,-9.21,;7.89,-10.7,;6.8,-11.79,;5.31,-11.39,;4.22,-12.48,;4.91,-9.9,)| | ||
| Structure | 
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