| Reaction Details |
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 | Report a problem with these data |
| Target | Programmed cell death 1 ligand 1 [19-239] |
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| Ligand | BDBM304279 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Homogenous Time-Resolved Fluorescence (HTRF) Binding Assay |
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| IC50 | 55±n/a nM |
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| Citation |  Allen, MP; Gillis, EP; Langley, DR; Miller, MM; Mull, E; Sun, L; Yeung, K; Grant-Young, KA; Meanwell, NA; Scola, PM Immunomodulators US Patent US10143746 Publication Date 12/4/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Programmed cell death 1 ligand 1 [19-239] |
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| Name: | Programmed cell death 1 ligand 1 [19-239] |
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| Synonyms: | B7H1 | CD274 | Human PD-L1(aa 19-239)-TVMV-His | PD-L1-His | PD1L1_HUMAN | PDCD1L1 | PDCD1LG1 | PDL1 | hPDL1(aa 19-239)-TVMV-His |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 27167.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NZQ7[19-239] |
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| Residue: | 237 |
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| Sequence: | FTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQH
SSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKIN
QRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLR
INTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTGSSETVRFQGHHHHHH
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| BDBM304279 |
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| n/a |
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| Name | BDBM304279 |
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| Synonyms: | US10143746, Example 1504 |
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| Type | Small organic molecule |
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| Emp. Form. | C87H117N21O20S |
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| Mol. Mass. | 1809.054 |
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| SMILES | CCCC[C@@H]1N(C)C(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H]2CCC(=O)NCC[C@H](NC(=O)[C@H](C)N(C)C(=O)[C@H](Cc3ccc(O)cc3)NC(=O)CSC[C@H](NC(=O)[C@H](C)NC1=O)C(=O)NCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N2 |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;$| |
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| Structure | 
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