| Reaction Details |
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 | Report a problem with these data |
| Target | PI3K/PI4K catalytic domain-containing protein |
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| Ligand | BDBM533837 |
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| Substrate/Competitor | n/a |
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| IC50 | >1000±n/a nM |
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| Citation |  Michael, YJ; Robert, TM; Peichao, L COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CRYPTOSPORIDIOSIS WIPOWO2022079616 Publication Date 4/21/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| PI3K/PI4K catalytic domain-containing protein |
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| Name: | PI3K/PI4K catalytic domain-containing protein |
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| Synonyms: | PI3K/PI4K domain-containing protein |
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| Type: | Protein |
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| Mol. Mass.: | 252626.40 |
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| Organism: | n/a |
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| Description: | A0A0S4TH36 |
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| Residue: | 2159 |
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| Sequence: | MSCGNKYFWNLEGHDPALALLDLFENGKKYNSLETLVDFLSKNIVLLENMKNNSNSKKEG
LFNFLFLFQKLNGRPAENENPEPVPLLSLDLKLADTILVQKALLRDLVFLLGNREFDVFR
RLYSLLIKFAPLDLKDLISIEKNHGSMICIYFTIYFSILLNIFGYENIGEFRKGEEIEEL
KLNWINKFVSQINDLLDYFIDKKTNLLRITDINNDCLILIFALILYLIISIIDIGNDKIT
EFKLAIIKLIKIQLSNLMFNYWYLKILLIIIERIGMDLTVSELVLVVLQYQKFIGEQSIK
IENNNSFDKSMNKLGVFETHIVTHLCRTWVVKEITLKKQLMEFVEQFIFTYGKLKEKKFD
DYFLKKEDDLSMLDPINIVFIKLVSLFSKAFGVSMTGIDKEEYKNKEISDSKEIDSLVLL
NLLEELLQGRRSQKICGLILFDSIRMLVTVLTILVDHRNFESENYDIKREIIQNDLVIVN
LHKGGWNLKAYKCIDLIEKLFEIITHLIIRYKEDHKELNNSVNTISSVSSSSTGSIFKTT
SFDISLFLIVWKNYVTLITRKEYRTDPIIFNKSIHLISLYLVSRKYKLDMLCEITFPISE
YSDNLPILLDERYSDLIDLWTILWRNYLNENTNLFYNKRDEVENIFTVPNINYFFEYLRI
LDQVITQNNGISSPGLALSDKESMYTQKFTTKVLELTGIISSILICHKIVHSSDRHNTLM
AILSASENPRIMSEYIYKQATNSLQFDGAYIYNCLKFFREKWSSSIKIRVFSLISDLYIS
IMKQSLFQFIQCLLSNFSVRGGIFEKSFALFKVRGMRGIISEEDFEVLQQKLTNIFSYSN
SDLDGDLTSSLIKNEIFFGCYSIDLYYTINNIQKGWQSPSLSITPSSPKTFLNKKRHSSL
MITDSEDVYSIINRLNPLFDQLINDDDYLKLFMDTVGEISKCYFYFLFENKSSDSGERSL
IDQISNFSTIFGVKFEDEKFMASMNLKNELLKNVNYSNPTEEVIVERFNYKFYSQLIIRM
IYLCTWMIVDNNYESYKSLSDLFAEKILNGLFGISNDEGGNHTSSYKFSQGNDQFDRFKS
SLTDDYVLEHYTKFVCIIWSIISSMDPESIYKSYIKILERESLSYYQLYILLVFLIESSD
WFIHHGYFQHINLLKILRQVELMTCLSSAYLQVKDENKEKTSQINSSDLHLKILLVCLIQ
KSITVEISKEVPLECYKKKHPTILKTNHNDLDIPQIRIYKFNNKSNQRDAYINGGRSMIS
TSYFLSCRILPYLWSFYESYPTYKDIYTRLLQSSTQLTTYLDNLCVNLYETKNWQKMMNN
FNNVHLESSVEIYDNRLIPYNQYIVLEYIWEYFINGNTMILIEKYISALIFSIYSSKKVG
FFEVWLLLSLWKRYPARIYRHMMKTSSTWIVPFLMDHLIHYSILVKNNYIGISSPKNDLI
RVFNNIELENTFSFLLYHYHPQYYHDRMSGKYFWYNASSEQGYLNKINSHNTEIKGLVMN
CRYTQGNHQLVLQFHDYLHYIGHSLPFPVVIYLLSNQFSSEKKKFMSNSHHFHNYFHHSL
YTSTLIVWSCVRSLLLSQESEWELLLLQYMEIIKSNKRNNQLVLTGLLDMALKSTRFSQI
LCIYTNNPNSPIMNIFQKSLFKECDFLLTCKSMKSSEENIERNEDQNMNGKYEKRNSSEI
HGKGVINRLRTVQDSMEGLNLRMSSVSSLINKCFDTISETSENLNRSSLNILQFENKKHS
LANVQFSFFYILCQLGEMAKYRNRKEGGLGLPIEEDDNPSALIGRLNSKEIAQLKSEIAQ
DLLAKIENVIQRKEYKNVPFLNTNMLKSSENKTKLLSIKKINKLKILQSAKNIPYLLSLQ
LTDHNSDNQDTLVDISKIEPEQDYEMTINLIVKCNDDCRQDVITMQYIHVFQKIFELYNI
PVWLYPYRILPMMFKDINNSVIYGGIIEFIEDSISLHEIHELHSEGGLKAYYESTFGGKN
SHIKKLENDNNVSYEQARYNFISSLAGYSIACYVLQIKDRHNGNILITKNGHIIHIDYGF
IFDISPGNNLHFERAAFKVTQEMLDFMDDQVDLFDDLCLSGFLAVREHADLLLSLTQMLI
NSGIPCFRGETIKKLKERLLLNFSQQQASNIFSKKIHSAHNHITTKGYDLVQFIQQGIK
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| BDBM533837 |
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| n/a |
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| Name | BDBM533837 |
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| Synonyms: | Methyl 2-chloro-5-(N-methyl-3-(3-methyl-4-(carbamoyl)phenyl)pyrazolo[1,5-a]pyridine-5-carboxamido)benzoate (1.22) | WO2022079616, Example 1.22 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H23ClN4O4 |
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| Mol. Mass. | 490.938 |
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| SMILES | CNC(=O)c1ccc(cc1C)-c1cnn2ccc(cc12)C(=O)N(C)c1ccc(Cl)c(c1)C(=O)OC |
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| Structure | 
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