| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 1 |
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| Ligand | BDBM534424 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | RIPK1 HTRF Binding Assay |
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| IC50 | 0.30±n/a nM |
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| Citation |  Guanglin, L; Jie, C; Diane, DC; B., FD; Junqing, G; C., HA; Xirui, H; E., MM; Reiser, PM; Jianliang, S; H., SS; Lee, VB; Yong-Jin, W; Zili, X; G., YM TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS WIPOWO2022086828 Publication Date 4/28/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-interacting serine/threonine-protein kinase 1 |
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| Name: | Receptor-interacting serine/threonine-protein kinase 1 |
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| Synonyms: | Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 75926.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13546 |
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| Residue: | 671 |
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| Sequence: | MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN
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| BDBM534424 |
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| n/a |
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| Name | BDBM534424 |
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| Synonyms: | 3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl)-N-(3-(4-chlorophenyl)-3-fluoropropyl)-2-fluoro-6-methylbenzamide | WO2022086828, Example 160 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H20ClF2N5O |
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| Mol. Mass. | 455.888 |
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| SMILES | Cc1ccc(c(F)c1C(=O)NCCC(F)c1ccc(Cl)cc1)-c1ccn2nc(N)nc2c1 |
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| Structure | 
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