| Reaction Details |
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 | Report a problem with these data |
| Target | Uromodulin |
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| Ligand | BDBM534824 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In-Vitro Assay |
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| IC50 | 34.0±n/a nM |
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| Citation |  Sharma, R; Iyer, P; Agarwal, S Substituted sulfoximine compounds US Patent US11236045 Publication Date 2/1/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Uromodulin |
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| Name: | Uromodulin |
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| Synonyms: | THP | Tamm-Horsfall urinary glycoprotein | UMOD | UROM_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 69744.65 |
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| Organism: | Human |
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| Description: | P07911 |
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| Residue: | 640 |
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| Sequence: | MGQPSLTWMLMVVVASWFITTAATDTSEARWCSECHSNATCTEDEAVTTCTCQEGFTGDG
LTCVDLDECAIPGAHNCSANSSCVNTPGSFSCVCPEGFRLSPGLGCTDVDECAEPGLSHC
HALATCVNVVGSYLCVCPAGYRGDGWHCECSPGSCGPGLDCVPEGDALVCADPCQAHRTL
DEYWRSTEYGEGYACDTDLRGWYRFVGQGGARMAETCVPVLRCNTAAPMWLNGTHPSSDE
GIVSRKACAHWSGHCCLWDASVQVKACAGGYYVYNLTAPPECHLAYCTDPSSVEGTCEEC
SIDEDCKSNNGRWHCQCKQDFNITDISLLEHRLECGANDMKVSLGKCQLKSLGFDKVFMY
LSDSRCSGFNDRDNRDWVSVVTPARDGPCGTVLTRNETHATYSNTLYLADEIIIRDLNIK
INFACSYPLDMKVSLKTALQPMVSALNIRVGGTGMFTVRMALFQTPSYTQPYQGSSVTLS
TEAFLYVGTMLDGGDLSRFALLMTNCYATPSSNATDPLKYFIIQDRCPHTRDSTIQVVEN
GESSQGRFSVQMFRFAGNYDLVYLHCEVYLCDTMNEKCKPTCSGTRFRSGSVIDQSRVLN
LGPITRKGVQATVSRAFSSLGLLKVWLPLLLSATLTLTFQ
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| BDBM534824 |
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| n/a |
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| Name | BDBM534824 |
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| Synonyms: | US11236045, Example 24 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N5O3S |
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| Mol. Mass. | 411.477 |
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| SMILES | COc1ccc(cn1)S(=O)(NC(=O)Nc1c2CCCc2cc2CCCc12)=NC#N |
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| Structure | 
|
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