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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Fibroblast growth factor receptor 3 | ||
| Ligand | BDBM651430 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | FGFR Enzymatic Assay | ||
| Ki | <10±n/a nM | ||
| Citation |  McCammant, MS; Styduhar, E; Vechorkin, O; Swyka, R; Yao, W Tricyclic heterocycles as FGFR inhibitors US Patent US11897891 Publication Date 2/13/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Fibroblast growth factor receptor 3 | |||
| Name: | Fibroblast growth factor receptor 3 | ||
| Synonyms: | CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4 | ||
| Type: | Protein | ||
| Mol. Mass.: | 87699.57 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P22607 | ||
| Residue: | 806 | ||
| Sequence: |
| ||
| BDBM651430 | |||
| n/a | |||
| Name | BDBM651430 | ||
| Synonyms: | US11897891, Example 45 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H27Cl2N7O | ||
| Mol. Mass. | 548.466 | ||
| SMILES | CN(C)C(=O)N[C@H]1CC[C@@H](CC1)n1cc(cn1)-c1cnc2ccn3cc(nc3c2c1)-c1c(Cl)cccc1Cl |r,wU:6.5,wD:9.12,(9.19,-2.56,;7.79,-1.93,;6.54,-2.83,;7.62,-.4,;8.87,.51,;6.22,.23,;4.97,-.68,;5.13,-2.21,;3.89,-3.11,;2.48,-2.49,;2.32,-.95,;3.57,-.05,;1.23,-3.39,;-.23,-2.92,;-1.14,-4.16,;-.23,-5.41,;1.23,-4.93,;-2.68,-4.16,;-3.45,-5.5,;-4.99,-5.5,;-5.76,-4.16,;-7.3,-4.16,;-8.07,-2.83,;-7.3,-1.49,;-7.77,-.03,;-6.53,.88,;-5.28,-.03,;-5.76,-1.49,;-4.99,-2.83,;-3.45,-2.83,;-6.53,2.42,;-7.86,3.19,;-9.19,2.42,;-7.86,4.73,;-6.53,5.5,;-5.19,4.73,;-5.19,3.19,;-3.86,2.42,)| | ||
| Structure | 
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