| Reaction Details |
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 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 3 |
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| Ligand | BDBM651431 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FGFR Enzymatic Assay |
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| Ki | <10±n/a nM |
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| Citation |  McCammant, MS; Styduhar, E; Vechorkin, O; Swyka, R; Yao, W Tricyclic heterocycles as FGFR inhibitors US Patent US11897891 Publication Date 2/13/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Fibroblast growth factor receptor 3 |
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| Name: | Fibroblast growth factor receptor 3 |
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| Synonyms: | CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4 |
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| Type: | Protein |
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| Mol. Mass.: | 87699.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22607 |
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| Residue: | 806 |
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| Sequence: | MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
DGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAE
EELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLK
RQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGE
GCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIIN
LLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQ
VARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKW
MAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT
HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSS
SSSGDDSVFAHDLLPPAPPSSGGSRT
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| BDBM651431 |
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| n/a |
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| Name | BDBM651431 |
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| Synonyms: | US11897891, Example 46 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H26Cl2N6O |
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| Mol. Mass. | 545.462 |
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| SMILES | CC(=O)N1CC2(C1)CCC(CC2)n1cc(cn1)-c1cnc2ccn3cc(nc3c2c1)-c1c(Cl)cccc1Cl |
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| Structure | 
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