| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands |
|---|
| Ligand | BDBM50389688 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Luminescent Kinase Assay |
|---|
| IC50 | 3.20±n/a nM |
|---|
| Citation |  Van Voorhis, WC; Hol, WG; Larson, ET; Maly, DJ; Merritt, E; Ojo, KK Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases US Patent US11247972 Publication Date 2/15/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands |
|---|
| Name: | Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands |
|---|
| Synonyms: | cGMP-dependent protein kinase (CpCDPK) |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 80612.61 |
|---|
| Organism: | Cryptosporidium parvum (strain Iowa II) |
|---|
| Description: | Q5CTY5 |
|---|
| Residue: | 718 |
|---|
| Sequence: | MMGQGQNALNGVCSRRYEKDSIEINKNKEVRRKQSNKRGNFPAHNMTHGKPEYLKEAVDR
LINHGNIVGNSPDRYLAKERKSQASCSTSDPTSPLAYRNGNDNYFEQYEICDLIELTSEM
ALSNESRFESLSEYESIPKLSPSTTVMGITDVSATNTSNSNSATPTESEKGSGPKLSLTE
GKFRREGLIPACKGSIHSDYIIDSGRIGKGTYGSVKSGTNRLTGCIRAIKTIPLTRVEAL
DNFMKEINILKNLDHPNIVKLYETYQDKENIYLVMELCSGGELFDRIISQGSFDEIYAAN
LMKQVLSTICYCHDHGIVHRDLKPENFLFLNKNYNAPLKIIDFGLAARVNNEDTSLNTRA
GTPYYVAPEVLQGKYDKQCDMWSLGVILYILLCGYPPFHGSNDSIILHKVQKGVYAFKEE
DWKHVSFLAIDLIRKLLTYNPSERITARDALNHPWITRFADDILFLSPRNYFYSNDGFMK
TGIVSSDYIDSSINNLKALECQQKPRNCNLMGSRRNGYIKGGLRYCRSKRRSISSSSGLN
LLSNFRAFHKYNRFMKVALTVIAQQMTESQISNLKEAFILLDANCDGTLTPQEIITGLKN
SGITELPSDLLAILNDIDSDGSGSIDYTEFIAATLDSKQYSKEQVCWAAFKVFDQDGNGK
ITANELLNVFSYNSEQGSAGINDKALSDVKNMIKEVDVDGDGEIDFQEFLEMFRRSNS
|
|
|
|---|
| BDBM50389688 |
|---|
| n/a |
|---|
| Name | BDBM50389688 |
|---|
| Synonyms: | CHEMBL2069315 | US10544104, Compound 36 | US11247972, Compound 36 | US9765037, Compound 36 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H26N6O |
|---|
| Mol. Mass. | 414.5028 |
|---|
| SMILES | Nc1ncnc2n(CC3CCNCC3)nc(-c3ccc4cc(OCC=C)ccc4c3)c12 |
|---|
| Structure | 
|
|---|
Search and Browse
