| Reaction Details |
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 | Report a problem with these data |
| Target | Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands |
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| Ligand | BDBM50389687 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Luminescent Kinase Assay |
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| IC50 | 4.10±n/a nM |
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| Citation |  Van Voorhis, WC; Hol, WG; Larson, ET; Maly, DJ; Merritt, E; Ojo, KK Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases US Patent US11247972 Publication Date 2/15/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands |
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| Name: | Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands |
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| Synonyms: | cGMP-dependent protein kinase (CpCDPK) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 80612.61 |
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| Organism: | Cryptosporidium parvum (strain Iowa II) |
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| Description: | Q5CTY5 |
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| Residue: | 718 |
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| Sequence: | MMGQGQNALNGVCSRRYEKDSIEINKNKEVRRKQSNKRGNFPAHNMTHGKPEYLKEAVDR
LINHGNIVGNSPDRYLAKERKSQASCSTSDPTSPLAYRNGNDNYFEQYEICDLIELTSEM
ALSNESRFESLSEYESIPKLSPSTTVMGITDVSATNTSNSNSATPTESEKGSGPKLSLTE
GKFRREGLIPACKGSIHSDYIIDSGRIGKGTYGSVKSGTNRLTGCIRAIKTIPLTRVEAL
DNFMKEINILKNLDHPNIVKLYETYQDKENIYLVMELCSGGELFDRIISQGSFDEIYAAN
LMKQVLSTICYCHDHGIVHRDLKPENFLFLNKNYNAPLKIIDFGLAARVNNEDTSLNTRA
GTPYYVAPEVLQGKYDKQCDMWSLGVILYILLCGYPPFHGSNDSIILHKVQKGVYAFKEE
DWKHVSFLAIDLIRKLLTYNPSERITARDALNHPWITRFADDILFLSPRNYFYSNDGFMK
TGIVSSDYIDSSINNLKALECQQKPRNCNLMGSRRNGYIKGGLRYCRSKRRSISSSSGLN
LLSNFRAFHKYNRFMKVALTVIAQQMTESQISNLKEAFILLDANCDGTLTPQEIITGLKN
SGITELPSDLLAILNDIDSDGSGSIDYTEFIAATLDSKQYSKEQVCWAAFKVFDQDGNGK
ITANELLNVFSYNSEQGSAGINDKALSDVKNMIKEVDVDGDGEIDFQEFLEMFRRSNS
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| BDBM50389687 |
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| n/a |
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| Name | BDBM50389687 |
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| Synonyms: | CHEMBL2070054 | US10544104, Compound 41 | US11247972, Compound 41 | US9765037, Compound 41 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21N5O |
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| Mol. Mass. | 359.4243 |
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| SMILES | CC(C)n1nc(-c2ccc3cc(OCC=C)ccc3c2)c2c(N)ncnc12 |
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| Structure | 
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