| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [1-18,20-1210] |
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| Ligand | BDBM538105 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibitory Ability Assay |
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| IC50 | 79.0±n/a nM |
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| Citation |  Lee, K; Shin, I; Choi, G; Chae, CH; Choe, HJ; Jung, ME; Jeon, BU; Cho, BC; Park, CW; Kim, H; Duggirala, KB N2,N4-diphenylpyrimidine-2,4-diamine derivative, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of cancer US Patent US11253516 Publication Date 2/22/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Epidermal growth factor receptor [1-18,20-1210] |
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| Name: | Epidermal growth factor receptor [1-18,20-1210] |
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| Synonyms: | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR)(del19) | HER1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 134176.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00533[1-18,20-1210] |
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| Residue: | 1209 |
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| Sequence: | MRPSGTAGAALLALLAALPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVV
LGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAV
LSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQ
NHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCT
GPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVV
TDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKN
CTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFE
NLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLF
GTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNL
LEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMG
ENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVA
LGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSG
AFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGIC
LTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAAR
NVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYG
VTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKF
RELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQ
GFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDS
IDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNT
VQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVA
PQSSEFIGA
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| BDBM538105 |
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| n/a |
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| Name | BDBM538105 |
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| Synonyms: | US11253516, Example 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26BrN7O3S |
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| Mol. Mass. | 548.456 |
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| SMILES | COc1cc(ccc1Nc1ncc(Br)c(Nc2ccccc2NS(N)(=O)=O)n1)C1CCNCC1 |
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| Structure | 
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