Reaction Details |
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Target | Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] |
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Ligand | BDBM538138 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibitory Ability Assay |
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IC50 | 0.400±n/a nM |
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Citation | Lee, K; Shin, I; Choi, G; Chae, CH; Choe, HJ; Jung, ME; Jeon, BU; Cho, BC; Park, CW; Kim, H; Duggirala, KB N2,N4-diphenylpyrimidine-2,4-diamine derivative, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of cancer US Patent US11253516 Publication Date 2/22/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] |
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Name: | Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] |
Synonyms: | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR)(del19/T790M/C797S) | HER1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 134190.47 |
Organism: | Homo sapiens (Human) |
Description: | P00533[1-18,20-1210,T790M,C797S] |
Residue: | 1209 |
Sequence: | MRPSGTAGAALLALLAALPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVV
LGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAV
LSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQ
NHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCT
GPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVV
TDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKN
CTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFE
NLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLF
GTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNL
LEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMG
ENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVA
LGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSG
AFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGIC
LTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAAR
NVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYG
VTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKF
RELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQ
GFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDS
IDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNT
VQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVA
PQSSEFIGA
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BDBM538138 |
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n/a |
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Name | BDBM538138 |
Synonyms: | US11253516, Example 40 |
Type | Small organic molecule |
Emp. Form. | C24H30ClN7O3S |
Mol. Mass. | 532.058 |
SMILES | CNC1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3ccccc3NS(C)(=O)=O)n2)c(OC)c1 |
Structure |
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