| Reaction Details |
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 | Report a problem with these data |
| Target | Short transient receptor potential channel 3 |
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| Ligand | BDBM542199 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Electrophysiology Assay |
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| IC50 | 6.22±n/a nM |
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| Citation |  Zhang, X; Pan, W; Nikitidis, G; Lindhagen, JS Cyclopentane compounds US Patent US11274091 Publication Date 3/15/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Short transient receptor potential channel 3 |
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| Name: | Short transient receptor potential channel 3 |
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| Synonyms: | TRP-3 | TRP3 | TRPC3 | TRPC3_HUMAN | Transient receptor protein 3 | hTrp-3 | hTrp3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 96009.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107641 |
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| Residue: | 836 |
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| Sequence: | MREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDY
MGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKR
LTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDY
FCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIE
KEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLA
IKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPC
SRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTT
QFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFL
QATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSR
IAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFT
TVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINS
SYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRR
RLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQV
DKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSMLRCE
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| BDBM542199 |
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| n/a |
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| Name | BDBM542199 |
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| Synonyms: | 1-[2-(3-amino-5-fluoro-1-piperidyl)-4-(4-fluorophenyl) cyclopentyl]pyrazole-4-carbonitrile | US11274091, Example 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23F2N5 |
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| Mol. Mass. | 371.4269 |
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| SMILES | NC1CC(F)CN(C1)C1CC(CC1n1cc(cn1)C#N)c1ccc(F)cc1 |
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| Structure | 
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