| Reaction Details |
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 | Report a problem with these data |
| Target | Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
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| Ligand | BDBM542558 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Bim Binding Assays (Mcl-1 TR-FRET Assays) |
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| Ki | 0.043±n/a nM |
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| Citation |  Rescourio, G; Gonzalez Buenrostro, A; Brown, SP; Lizarzaburu, M; Medina, J; Jabri, SY; Sun, D; Simonovich, SP; Yan, X; Li, Y; Rew, Y Alpha-hydroxy phenylacetic acid pharmacophore or bioisostere Mcl-1 protein antagonists US Patent US11274105 Publication Date 3/15/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
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| Name: | Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
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| Synonyms: | Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] | Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]/Bcl-2-like protein 11 [51-76] | Mcl-1 and BIM | Mcl-1/BIM |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
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| Synonyms: | BCL2L3 | Induced myeloid leukemia cell differentiation protein Mcl-1(171-327) | MCL1 | MCL1_HUMAN | Myeloid cell leukemia 1 (Mcl-1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 17896.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07820[171-327] |
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| Residue: | 157 |
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| Sequence: | EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQG
MLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPL
AESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
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| Component 2 |
| Name: | Bcl-2-like protein 11 [51-76] |
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| Synonyms: | B2L11_HUMAN | BCL2L11 | BIM | Bcl-2-like protein 11 (51-76) | Bcl-2-like protein 11 (BIM) (51-76) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 2530.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43521[51-76] |
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| Residue: | 26 |
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| Sequence: | EGDSCPHGSP QGPLAPPASP GPFATR
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| BDBM542558 |
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| n/a |
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| Name | BDBM542558 |
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| Synonyms: | (1S,3′R,6′R,7′S,8′E,15′R)-6-CHLORO-N-(CYCLOPROPYLSULFONYL)-7′,15′-DIHYDROXY-12′-METHYL-13′-OXO-3,4-DIHYDRO-2H-SPIRO[NAPHTHALENE-1,22′-[20]OXA[1,12]DIAZA TETRACYCLO[14.7.2.03,6.019,24]PENTACOSA[8,16,18,24] TETRAENE]-15′-CARBOXAMIDE | US11274105, Example 45 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H44ClN3O7S |
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| Mol. Mass. | 698.268 |
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| SMILES | CN1CC\C=C\[C@H](O)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)[C@](O)(CC1=O)C(=O)NS(=O)(=O)C1CC1 |r,t:4| |
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| Structure | 
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