Reaction Details |
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Target | Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
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Ligand | BDBM542589 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Bim Binding Assays (Mcl-1 TR-FRET Assays) |
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Ki | 0.092±n/a nM |
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Citation | Rescourio, G; Gonzalez Buenrostro, A; Brown, SP; Lizarzaburu, M; Medina, J; Jabri, SY; Sun, D; Simonovich, SP; Yan, X; Li, Y; Rew, Y Alpha-hydroxy phenylacetic acid pharmacophore or bioisostere Mcl-1 protein antagonists US Patent US11274105 Publication Date 3/15/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
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Name: | Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
Synonyms: | Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] | Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]/Bcl-2-like protein 11 [51-76] | Mcl-1 and BIM | Mcl-1/BIM |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
Synonyms: | BCL2L3 | Induced myeloid leukemia cell differentiation protein Mcl-1(171-327) | MCL1 | MCL1_HUMAN | Myeloid cell leukemia 1 (Mcl-1) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 17896.13 |
Organism: | Homo sapiens (Human) |
Description: | Q07820[171-327] |
Residue: | 157 |
Sequence: | EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQG
MLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPL
AESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
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Component 2 |
Name: | Bcl-2-like protein 11 [51-76] |
Synonyms: | B2L11_HUMAN | BCL2L11 | BIM | Bcl-2-like protein 11 (51-76) | Bcl-2-like protein 11 (BIM) (51-76) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 2530.22 |
Organism: | Homo sapiens (Human) |
Description: | O43521[51-76] |
Residue: | 26 |
Sequence: | EGDSCPHGSP QGPLAPPASP GPFATR
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BDBM542589 |
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n/a |
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Name | BDBM542589 |
Synonyms: | (3R,6R,7S,11S,17R,24S)-6′-CHLORO-N-(CYCLOPROPYLSULFONYL)-17-HYDROXY-14-METHYL-15-OXO-3′,4′-DIHYDRO-2′H-SPIRO[8,22-DIOXA-1,14-DIAZAPENTACYCLO [16.7.2.17,11.03,6.021,26]OCTACOSA-18,20,26-TRIENE-24,1′-NAPHTHALENE]-17-CARBOXAMIDE | US11274105, Example 79 |
Type | Small organic molecule |
Emp. Form. | C38H48ClN3O7S |
Mol. Mass. | 726.322 |
SMILES | CN1CC[C@H]2CCO[C@@H](C2)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)[C@](O)(CC1=O)C(=O)NS(=O)(=O)C1CC1 |r| |
Structure |
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