| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Macrophage colony-stimulating factor 1 receptor |
|---|
| Ligand | BDBM542816 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Studies |
|---|
| IC50 | 5.00±n/a nM |
|---|
| Citation |  Kane, Jr., JL; Barberis, C; Czekaj, M; Erdman, P; Giese, B; Kothe, M; Le, T; Liu, J; Ma, L; Metz, M; Patel, V; Scholte, A; Shum, PW; Wei, L Colony stimulating factor-1 receptor (CSF-1R) inhibitors US Patent US11274108 Publication Date 3/15/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Macrophage colony-stimulating factor 1 receptor |
|---|
| Name: | Macrophage colony-stimulating factor 1 receptor |
|---|
| Synonyms: | CSF1R | CSF1R_HUMAN | FMS | Fms proto-oncogene | Macrophage colony stimulating factor receptor | Macrophage colony-stimulating factor 1 receptor (FMS) | Macrophage colony-stimulating factor 1 receptor (c-FMS) | Macrophage colony-stimulating factor 1 receptor (cFMS) | Proto-oncogene c-Fms | Tyrosine Kinase CSF1-R | c-fms | cFMS |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 107979.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P07333 |
|---|
| Residue: | 972 |
|---|
| Sequence: | MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTL
YSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFED
QDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSAL
MGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHN
NTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAY
LNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTY
RHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCA
ASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHN
QTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKY
KQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEAT
AFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVL
VITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGV
DTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVA
ARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWS
YGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR
PTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIA
QPLLQPNNYQFC
|
|
|
|---|
| BDBM542816 |
|---|
| n/a |
|---|
| Name | BDBM542816 |
|---|
| Synonyms: | 3-((8-methoxy-2-(6-methoxypyridin-3-yl)-2,3- dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-6-((1- methylazetidin-3-yl)oxy)pyrazolo[1,5-a]pyrimidine | 3-((8-methoxy-2-(6-methoxypyridin-3-yl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-6-((1-methylazetidin-3-yl)oxy)pyrazolo[1,5-a]pyrimidine | US11274108, Example 1-101 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H27N5O5 |
|---|
| Mol. Mass. | 489.5231 |
|---|
| SMILES | COc1ccc(cn1)C1COc2cc(Cc3cnn4cc(OC5CN(C)C5)cnc34)cc(OC)c2O1 |
|---|
| Structure | 
|
|---|
Search and Browse
