| Reaction Details |
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 | Report a problem with these data |
| Target | 5'-AMP-activated protein kinase catalytic subunit alpha-1 |
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| Ligand | BDBM543471 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro pAMPK1 Kinase Activation Assay |
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| EC50 | 0.970±n/a nM |
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| Citation |  Sebhat, I; He, S AMPK activators US Patent US11279702 Publication Date 3/22/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| 5'-AMP-activated protein kinase catalytic subunit alpha-1 |
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| Name: | 5'-AMP-activated protein kinase catalytic subunit alpha-1 |
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| Synonyms: | AAPK1_HUMAN | ACACA kinase | AMP-activated protein kinase alpha-1/beta-2/gamma-2 | AMP-activated protein kinase, alpha-1 subunit | AMPK subunit alpha-1 | AMPK-alpha1 | AMPK1 | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA1 | Tau-protein kinase PRKAA1 |
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| Type: | Protein |
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| Mol. Mass.: | 64023.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13131 |
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| Residue: | 559 |
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| Sequence: | MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR
QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG
RLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF
LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDG
IFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMID
DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDS
FLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDI
MAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDE
ITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPG
SHTIEFFEMCANLIKILAQ
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| BDBM543471 |
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| n/a |
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| Name | BDBM543471 |
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| Synonyms: | (((6-chloro-5-(2'-hydroxy-[1,1'-biphenyl]-4- yl)-1H-imidazo[4,5-b]pyridin-2- yl)thio)methyl)(methyl)phosphinic acid | US11279702, Compound 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H17ClN3O3PS |
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| Mol. Mass. | 445.859 |
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| SMILES | CP(O)(=O)CSc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccccc1O |
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| Structure | 
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