| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK1 [837-1142] |
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| Ligand | BDBM400612 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro JAK Kinase Assay |
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| IC50 | <5±n/a nM |
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| Citation |  Huang, T; Xue, C Piperidin-4-yl azetidine derivatives as JAK1 inhibitors US Patent US11285140 Publication Date 3/29/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK1 [837-1142] |
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| Name: | Tyrosine-protein kinase JAK1 [837-1142] |
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| Synonyms: | JAK1 | JAK1 (aa 837-1142) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (837-1142) | Tyrosine-protein kinase JAK1 (aa 837-1142) |
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| Type: | n/a |
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| Mol. Mass.: | 35230.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23458[837-1142] |
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| Residue: | 306 |
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| Sequence: | FFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDP
EGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIM
EFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQ
VKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLT
YCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQP
SNRTSF
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| BDBM400612 |
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| n/a |
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| Name | BDBM400612 |
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| Synonyms: | US10695337, Example 368 | US11285140, Example 368 | US9999619, Example 368 | {1-{1-[6-[(dimethylamino)methyl]-3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile |
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| Type | Small organic molecule |
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| Emp. Form. | C29H30F4N10O |
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| Mol. Mass. | 610.6085 |
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| SMILES | CN(C)Cc1cc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c(F)c(n1)C(F)(F)F |
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| Structure | 
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