| Reaction Details |
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 | Report a problem with these data |
| Target | Monocarboxylate transporter 4 |
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| Ligand | BDBM345284 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Activity Assay 3 |
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| IC50 | 8.80±n/a nM |
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| Citation |  Parnell, KM; McCall, J; Romero, D Heterocyclic inhibitors of MCT4 US Patent US11292767 Publication Date 4/5/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Monocarboxylate transporter 4 |
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| Name: | Monocarboxylate transporter 4 |
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| Synonyms: | MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49474.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_104604 |
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| Residue: | 465 |
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| Sequence: | MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDT
AWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGV
ITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGF
LILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVL
GLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSF
SMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVL
LMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPE
VAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
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| BDBM345284 |
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| n/a |
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| Name | BDBM345284 |
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| Synonyms: | 2-[[1-[(2-Bromophenyl)methyl]-5-(3- methoxyphenyl)-1H-pyrazol-3- yl]methoxy]-2-methylpropanoic acid 1HNMR (CDCl3): $#948; 1.56 (s, 6H), 3.65 (s, 3H), 4.62 (s, 2H), 5.39 (s, 2H), 6.41 (s, 1H), 6.73-6.76 (m 2H), 6.84-6.92 (m, 2H), 7.15 (t, 1H), 7.13-7.29 (m, 2H), 7.52- 7.54 (m, 1H). | US10202350, Example 30 | US10214492, Example 30 | US11292767, Example 30 | US11724989, Example 30 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23BrN2O4 |
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| Mol. Mass. | 459.333 |
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| SMILES | COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Br |
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| Structure | 
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