Ki Summary

Reaction Details

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Target

Glucan 1,4-alpha-glucosidase

Ligand

BDBM23406

Substrate/Competitor

n/a

Meas. Tech.

Property Evaluation 3

IC50

126±6 nM

Citation

Na, DH; Kang, KP; Jun, JH; Go, G; Na, HJ; Kang, SJ; Na, YH; Yoon, SJ; Na, SJ Composition for inhibiting growth of SARS-CoV-2 and method of preparing the same US Patent US11292789 Publication Date 4/5/2022

More Info.:

Get all data from this article, Assay Method

Glucan 1,4-alpha-glucosidase

Name:

Glucan 1,4-alpha-glucosidase

Synonyms:

1,4-alpha-D-glucan glucohydrolase | Glucan 1,4-alpha-glucosidase

Type:

Protein

Mol. Mass.:

58125.45

Organism:

Shiitake mushroom

Description:

A0A1Q3E5G6

Residue:

534

Sequence:

MLSNSANDYIQREGPLAQAGLLANIGPNGNQASAAAPGIAIASPSTSNPNYLYSWTRDAA
LVFKVIVDHYARSPAPRDLSLRTLIDSYADAQSRLQEVENPSGNITTGGLGEPKFNIDLT
AFTGSWDLNAMALLDLDYVADNWNKTGFDLWEEVSSSSFWTTAAQHRALRQGAELAKTLS
KDDLAESYSTQADNALCFLQSYWNPNGSYITSNTGGGRSGIDANSILASIHSFDPSAGCD
ALTFQPCSDKALSNLKAYVDSFKTIYGINEGFSENEAIATGRYPEDIYMEGNPWYLTTFA
VAEQLYDSLSVWDAQGSLQITPVSLSFFQQFSSNVQTGNYGADSQTYGTLTSKIRAFADG
FIAVNGNYTPESGSLAEQYGKDDGKPTSARDLTWSYASAITSFLAHDGIVPTPWGAQGLQ
IRRDANGHCISNPGPMSEIVFEVERNTLYGENVYITGSIGQLGDWEPANAVRLEPKNYPS
WTVRIEIPASTTFSYKYIVQDQRSGQVTWENDPNHEVASPFKGQSVVLSDTWHD

BDBM23406

n/a

Name

BDBM23406

Synonyms:

(3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}oxan-2-yl]oxy}-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-(hydroxymethyl)oxane-2,3,4-triol | Acarbose | US11292789, Acarbose

Type

Carbohydrate

Emp. Form.

C25H43NO18

Mol. Mass.

645.6048

SMILES

C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)OC(O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O |t:37|

Structure