Reaction Details |
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Target | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
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Ligand | BDBM548256 |
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Substrate/Competitor | n/a |
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Meas. Tech. | VPS34 ADP-Glo kinase assay |
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IC50 | 4900±n/a nM |
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Citation | Snahel, P; Michael, S; Shumei, W; Huifen, C; X., HD SUBSTITUTED MORPHOLINE COMPOUNDS WIPOWO2022093820 Publication Date 5/5/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Phosphatidylinositol 3-kinase catalytic subunit type 3 |
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Name: | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
Synonyms: | BC033004 | PI3K type 3 | PIK3C3 | PK3C3_HUMAN | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) | Phosphatidylinositol 3-kinase p100 subunit | Phosphoinositide 3-Kinase (PI3K), Vps34 | Phosphoinositide-3-kinase class 3 | PtdIns-3-kinase type 3 | VPS34 | hVPS34 |
Type: | Enzyme |
Mol. Mass.: | 101551.30 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human Vps34 protein was expressed as monomeric GST-fusion and purified. |
Residue: | 887 |
Sequence: | MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVT
CQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAV
PVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTK
AHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDG
DESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIV
SYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDV
EDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKK
DSQSSVSENVSNSGINSAEIDSSQIITSPLPSVSSPPPASKTKEVPDGENLEQDLCTFLI
SRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRS
LLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVK
IRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRK
ENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAE
VMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLN
KEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVK
KVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK
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BDBM548256 |
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n/a |
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Name | BDBM548256 |
Synonyms: | (6S,7S)-7- cyclopropyl-6-methyl-2-((R)-3-methylmorpholino)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)- one | WO2022093820, Compound 22 |
Type | Small organic molecule |
Emp. Form. | C15H22N4O2 |
Mol. Mass. | 290.3608 |
SMILES | C[C@@H]1COCCN1c1cc2C(=O)N[C@@H](C)[C@H](C3CC3)n2n1 |r| |
Structure |
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