Reaction Details |
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Target | Mitogen-activated protein kinase kinase kinase kinase 1 |
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Ligand | BDBM548763 |
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Substrate/Competitor | n/a |
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Meas. Tech. | HPK1-SLP76 TR-FRET ASSAY |
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IC50 | 0.05±n/a nM |
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Citation | A., CD; L., CJ; Anthony, D; Xavier, F; H., FP; Shuhei, K; Bing, L; Jongwon, L; Ping, L; L., MJ; G., NA; Alexander, P; A., VB; C., YE 7-PHENYL SUBSTITUTED 2-AMINOQUINAZOLINE INHIBITORS OF HPK1 WIPOWO2022098806 Publication Date 5/12/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase kinase kinase kinase 1 |
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Name: | Mitogen-activated protein kinase kinase kinase kinase 1 |
Synonyms: | HPK1 | M4K1_HUMAN | MAP4K1 |
Type: | PROTEIN |
Mol. Mass.: | 91316.07 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_586597 |
Residue: | 833 |
Sequence: | MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
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BDBM548763 |
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n/a |
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Name | BDBM548763 |
Synonyms: | WO2022098806, Compound 2-114 | WO2022098806, Compound 2-123 | WO2022098806, Compound 2-24 |
Type | Small organic molecule |
Emp. Form. | C24H23FN6O3S |
Mol. Mass. | 494.541 |
SMILES | Cc1c2NCCOc2ncc1-c1cc2nc(Nc3ccc(CS(C)(=O)=O)cc3)ncc2c(N)c1F |
Structure |
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