| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Microtubule-associated protein tau |
|---|
| Ligand | BDBM551405 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Radioligand In Vitro Binding Assays on Recombinant and Native Tau Protein |
|---|
| IC50 | 10.0±n/a nM |
|---|
| Citation |  Mercier, J; Provins, L; Vermeiren, C; Sabnis, YA 9H-pyrrolo-dipyridine derivatives US Patent US11312716 Publication Date 4/26/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Microtubule-associated protein tau |
|---|
| Name: | Microtubule-associated protein tau |
|---|
| Synonyms: | MAPT | MAPTL | MTBT1 | Microtubule-associated protein tau | Neurofibrillary tangle protein | PHF-tau | Paired helical filament-tau | TAU | TAU_HUMAN | Tau Protein |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 78928.63 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P10636 |
|---|
| Residue: | 758 |
|---|
| Sequence: | MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPG
SETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAG
HVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEG
GRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPA
QDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLE
FTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPA
AAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSS
DPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQK
GQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREP
KKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLD
LSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEK
LDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDT
SPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
|
|
|
|---|
| BDBM551405 |
|---|
| n/a |
|---|
| Name | BDBM551405 |
|---|
| Synonyms: | N-methyl-5-(9H-pyrrolo[2,3-b: 4,5-c']dipyridin-2- | US11312716, Example 11 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H13N5O |
|---|
| Mol. Mass. | 303.318 |
|---|
| SMILES | CNC(=O)c1ccc(cn1)-c1ccc2c(n1)[nH]c1ccncc21 |
|---|
| Structure | 
|
|---|
Search and Browse
