| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase BTK |
|---|
| Ligand | BDBM174406 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzymatic Activity Assay |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 24±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Owens, TD Tyrosine kinase inhibitors US Patent US9688676 Publication Date 6/27/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase BTK |
|---|
| Name: | Tyrosine-protein kinase BTK |
|---|
| Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 76289.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q06187 |
|---|
| Residue: | 659 |
|---|
| Sequence: | MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
|
|
|
|---|
| BDBM174406 |
|---|
| n/a |
|---|
| Name | BDBM174406 |
|---|
| Synonyms: | US9688676, 8 (R)-2-(3-(4-amino-2-oxo-3-(4-phenoxyphenyl)-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)piperidine-1-carbonyl)-3-cyclobutylacrylonitrile |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H30N6O3 |
|---|
| Mol. Mass. | 534.6083 |
|---|
| SMILES | Nc1nccc2n([C@@H]3CCCN(C3)C(=O)C(=CC3CCC3)C#N)c(=O)n(-c3ccc(Oc4ccccc4)cc3)c12 |r,w:16.17| |
|---|
| Structure | 
|
|---|
Search and Browse
