| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 26B1 |
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| Ligand | BDBM476234 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Retinoid Activity Assays |
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| IC50 | 11920±n/a nM |
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| Citation |  Cameron, DA; Petkovich, M; Rantanen, TK; Snieckus, V; Board, J; Singh, S; Maheta, AJ Compounds and methods for inhibiting CPY26 enzymes US Patent US11364220 Publication Date 6/21/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 26B1 |
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| Name: | Cytochrome P450 26B1 |
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| Synonyms: | CP26B_HUMAN | CYP26A2 | CYP26A2 | CYP26B1 | Cytochrome P450 26A2 | Cytochrome P450 26B1 | Cytochrome P450 retinoic acid-inactivating 2 | Cytochrome P450RAI-2 | P450RAI2 | Retinoic acid-metabolizing cytochrome |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57525.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_115648 |
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| Residue: | 512 |
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| Sequence: | MLFEGLDLVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIG
ETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRS
TRMLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAIN
VYQEAQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRRGIQAR
QILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYAT
TASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKE
VMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQA
RSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVL
HPVDGLSVKFFGLDSNQNEILPETEAMLSATV
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| BDBM476234 |
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| n/a |
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| Name | BDBM476234 |
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| Synonyms: | US10874634, Cmpd No. 16 | US11364220, Compound 16 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H33NO3 |
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| Mol. Mass. | 407.5451 |
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| SMILES | Cc1cc2c(cc1C(=O)Nc1ccc(cc1)C(C)(C)C(O)=O)C(C)(C)CCC2(C)C |
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| Structure | 
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