| Reaction Details |
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 | Report a problem with these data |
| Target | Lysophosphatidic acid receptor 1 |
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| Ligand | BDBM557833 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | LPAR1 Membrane Binding Assay |
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| Ki | 94.8±n/a nM |
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| Citation |  Ma, T; Wu, L; Zhang, X Lysophosphatidic acid receptor 1 (LPAR1) inhibitor compounds US Patent US11365185 Publication Date 6/21/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysophosphatidic acid receptor 1 |
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| Name: | Lysophosphatidic acid receptor 1 |
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| Synonyms: | EDG2 | LPA receptor 1 | LPA-1 | LPA1 | LPAR1 | LPAR1_HUMAN | Lysophosphatidic acid receptor 1 (LPA1) | Lysophosphatidic acid receptor Edg-2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41120.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92633 |
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| Residue: | 364 |
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| Sequence: | MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVC
IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVST
WLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMS
RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLA
EFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSND
HSVV
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| BDBM557833 |
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| n/a |
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| Name | BDBM557833 |
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| Synonyms: | 1-[3-(cyanomethyl)-4-[6-[5-[(6-isopropylpyrazin-2-yl)amino]-1-methyl-pyrazol-4-yl]-3-pyridyl]phenyl]cyclopropanecarboxylic Acid; Hydrochloride | US11365185, Example 15B |
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| Type | Small organic molecule |
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| Emp. Form. | C28H27N7O2 |
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| Mol. Mass. | 493.5597 |
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| SMILES | CC(C)c1cncc(Nc2c(cnn2C)-c2ccc(cn2)-c2ccc(cc2CC#N)C2(CC2)C(O)=O)n1 |
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| Structure | 
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