| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor tyrosine-protein kinase erbB-2 [1-775,'VC',777-1255] |
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| Ligand | BDBM557881 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cell Viability Assay and IC50 Estimation |
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| IC50 | 520±n/a nM |
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| Citation |  Heymach, J; Robichaux, J; Nilsson, M; Jones, P; Cross, J; Theroff, J Heterocyclic inhibitors of tyrosine kinase US Patent US11365189 Publication Date 6/21/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor tyrosine-protein kinase erbB-2 [1-775,'VC',777-1255] |
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| Name: | Receptor tyrosine-protein kinase erbB-2 [1-775,'VC',777-1255] |
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| Synonyms: | ERBB2 | ERBB2_HUMAN | HER2 | Her2 G776delinsVC(VC) | MLN19 | NEU | NGL |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 138039.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P04626[1-775,'VC',777-1255] |
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| Residue: | 1256 |
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| Sequence: | MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL
ELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLA
LTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQC
AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSAN
IQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLP
DLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQEC
VEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARC
PSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVG
ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL
RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAVCVGS
PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDV
RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF
THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCW
MIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVD
AEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSE
GAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEY
VNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTP
QGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
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| BDBM557881 |
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| n/a |
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| Name | BDBM557881 |
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| Synonyms: | 1-(3-((4-((4-bromo-3- chlorophenyl)amino)- pyrido[3,2-d]pyrimidin-6- yl)oxy)azetidin-1-yl)prop-2- en-1-one | US11365189, Ex. No. 99 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15BrClN5O2 |
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| Mol. Mass. | 460.712 |
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| SMILES | Clc1cc(Nc2ncnc3ccc(OC4CN(C4)C(=O)C=C)nc23)ccc1Br |
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| Structure | 
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