| Reaction Details |
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 | Report a problem with these data |
| Target | Heme ligase |
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| Ligand | BDBM558638 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TBD |
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| IC50 | 5620±300 nM |
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| Citation |  Bhattacharya, AK; Aratikatla, EK; Malhotra, P; Mohmmed, A Antimalarial compounds, process for preparation and their use for drug resistant malaria US Patent US11365202 Publication Date 6/21/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Heme ligase |
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| Name: | Heme ligase |
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| Synonyms: | 4.99.1.8 | HDP | HDP_PLAF7 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 24349.37 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | ChEMBL_117325 |
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| Residue: | 205 |
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| Sequence: | MKNRFYYNLIIKRLYTRSGGLRKPQKVTNDPESINRKVYWCFEHKPVKRTIINLIYSHNE
LKIFSNLLNHPTVGSSLIHELSLDGPYTAFFPSNEAMQLINIESFNKLYNDENKLSEFVL
NHVTKEYWLYRDLYGSSYQPWLMYNEKREAPEKLRNLLNNDLIVKIEGEFKHCNHSIYLN
GSKIIRPNMKCHNGVVHIVDKPIIF
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| BDBM558638 |
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| n/a |
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| Name | BDBM558638 |
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| Synonyms: | US11365202, Compound 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C45H64N3O12P |
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| Mol. Mass. | 869.9763 |
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| SMILES | CCOP(=O)(OCC)\C=C\C(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO[C@H]1O[C@@H]2O[C@]3(C)CC[C@H]4[C@H](C)CC[C@@H]([C@H]1C)[C@@]24OO3)NC(=O)OCc1ccccc1)c1ccccc1 |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;N;;;;;;;;;;;;;;;;$| |
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| Structure | 
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