Reaction Details |
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Target | Apoptosis regulator Bcl-2 |
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Ligand | BDBM189671 |
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Substrate/Competitor | n/a |
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Meas. Tech. | TBDTR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) Assay |
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Ki | <0.010±n/a nM |
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Citation | Birtalan, E; Hoelig, P; Lindley, DJ; Sanzgiri, YD; Tong, P Melt-extruded solid dispersions containing an apoptosis-inducing agent US Patent US11369599 Publication Date 6/28/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Apoptosis regulator Bcl-2 |
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Name: | Apoptosis regulator Bcl-2 |
Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
Type: | Homodimer or heterodimer |
Mol. Mass.: | 26269.11 |
Organism: | Homo sapiens (Human) |
Description: | P10415 |
Residue: | 239 |
Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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BDBM189671 |
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n/a |
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Name | BDBM189671 |
Synonyms: | US10213433, Compound 240 | US11369599, Compound 240 | US20240043404, Example 240 | US9174982, 240 |
Type | Small organic molecule |
Emp. Form. | C49H57ClF3N7O6S2 |
Mol. Mass. | 996.598 |
SMILES | CC(C)(C)N1CCC(CC1)Nc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC(C)(C)CC2)c2ccc(Cl)cc2)CC1 |t:56| |
Structure |
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