Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Apoptosis regulator Bcl-2 | ||
Ligand | BDBM189778 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | TBDTR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) Assay | ||
Ki | <0.010±n/a nM | ||
Citation | Birtalan, E; Hoelig, P; Lindley, DJ; Sanzgiri, YD; Tong, P Melt-extruded solid dispersions containing an apoptosis-inducing agent US Patent US11369599 Publication Date 6/28/2022 | ||
More Info.: | Get all data from this article, Assay Method | ||
Apoptosis regulator Bcl-2 | |||
Name: | Apoptosis regulator Bcl-2 | ||
Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein | ||
Type: | Homodimer or heterodimer | ||
Mol. Mass.: | 26269.11 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P10415 | ||
Residue: | 239 | ||
Sequence: |
| ||
BDBM189778 | |||
n/a | |||
Name | BDBM189778 | ||
Synonyms: | US11369599, Compound 350 | US9174982, 350 | ||
Type | Small organic molecule | ||
Emp. Form. | C45H49Cl2FN6O6S | ||
Mol. Mass. | 891.877 | ||
SMILES | CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3cnc(OCC4(F)CCC(O)CC4)c(Cl)c3)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:57,(-2.44,-10.6,;-1.63,-9.3,;-3.17,-9.35,;-1.63,-7.76,;-.29,-6.99,;1.04,-7.76,;2.37,-6.99,;2.37,-5.45,;3.71,-4.68,;3.71,-3.14,;2.37,-2.37,;1.04,-3.14,;1.04,-4.68,;2.37,-.83,;3.71,-.06,;3.71,1.48,;2.37,2.25,;2.37,3.79,;1.04,4.56,;3.71,4.56,;5.04,3.79,;5.81,5.13,;4.27,2.46,;6.38,3.02,;6.38,1.48,;7.71,.71,;9.04,1.48,;10.38,.71,;10.38,-.83,;11.71,-1.6,;11.6,-.06,;13.25,-1.54,;14.07,-2.85,;13.34,-4.21,;14.16,-5.51,;11.8,-4.26,;10.99,-2.96,;9.04,3.02,;10.38,3.79,;7.71,3.79,;1.04,1.48,;-.29,2.25,;-1.63,1.48,;-1.63,-.06,;-2.96,-.83,;-4.29,-.06,;-5.76,-.53,;-6.66,.71,;-5.76,1.96,;-4.29,1.48,;-2.96,2.25,;1.04,-.06,;1.04,-9.3,;-.29,-10.07,;2.37,-10.07,;3.71,-9.3,;5.04,-10.07,;5.04,-11.61,;6.38,-12.38,;3.71,-12.38,;2.37,-11.61,)| | ||
Structure |