Reaction Details |
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Target | Cytochrome P450 11B1, mitochondrial |
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Ligand | BDBM8591 |
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Substrate/Competitor | BDBM8582 |
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Meas. Tech. | CYP11B assay |
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pH | 7.4±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 320±n/a nM |
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Citation | Ulmschneider, S; Muller-Vieira, U; Klein, CD; Antes, I; Lengauer, T; Hartmann, RW Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase. J Med Chem48:1563-75 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Cytochrome P450 11B1, mitochondrial |
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Name: | Cytochrome P450 11B1, mitochondrial |
Synonyms: | C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH |
Type: | Enzyme |
Mol. Mass.: | 57591.44 |
Organism: | Homo sapiens (Human) |
Description: | P15538 |
Residue: | 503 |
Sequence: | MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
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BDBM8591 |
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BDBM8582 |
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Name | BDBM8591 |
Synonyms: | (3-Pyridylmethylene)indane 9b | 3-{[(1Z)-5-bromo-2,3-dihydro-1H-inden-1-ylidene]methyl}pyridine |
Type | Small organic molecule |
Emp. Form. | C15H12BrN |
Mol. Mass. | 286.166 |
SMILES | Brc1ccc2\C(CCc2c1)=C/c1cccnc1 |
Structure |
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