Ki Summary

Reaction Details

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Target

Orexin receptor type 2

Ligand

BDBM559656

Substrate/Competitor

n/a

Meas. Tech.

IP-One Assay

IC50

0.09±n/a nM

Citation

L., BS; Ping, C; James, CD; Jian, L; T., RM; Li, X; Dexi, Y; Shishi, L 3-AMINO PYRROLIDINE AND PIPERIDINE MACROCYCLIC OREXIN RECEPTOR AGONISTS WIPOWO2022109117 Publication Date 5/27/2022

More Info.:

Get all data from this article, Assay Method

Orexin receptor type 2

Name:

Orexin receptor type 2

Synonyms:

Type:

Protein

Mol. Mass.:

50710.53

Organism:

Homo sapiens (Human)

Description:

O43614

Residue:

444

Sequence:

MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW

BDBM559656

n/a

Name

BDBM559656

Synonyms:

WO2022109117, Example 1

Type

Small organic molecule

Emp. Form.

C23H33N3O5S

Mol. Mass.

463.59

SMILES

C[C@@H]1C[C@H](NS(=O)(=O)N(C)C)[C@@H]2CO[C@H]3CC[C@H](CC3)c3ccccc3\C=C/OC(=O)N12 |wU:1.0,3.3,14.19,17.17,11.34,c:28,(7.84,-2.1,;6.55,-1.27,;6.46,.27,;4.97,.66,;4.41,2.09,;5.37,3.29,;6.57,2.33,;4.17,4.26,;6.33,4.5,;5.77,5.93,;7.86,4.26,;4.14,-.64,;2.72,.03,;1.13,.06,;-.2,-.85,;.94,-1.91,;.69,-3.42,;-.71,-4.05,;-1.86,-2.99,;-1.66,-1.45,;-.07,-5.54,;-1.54,-6.01,;-1.86,-7.52,;-.72,-8.55,;.75,-8.08,;1.07,-6.57,;2.72,-6.8,;4.2,-6.14,;5.18,-4.87,;5.49,-3.35,;7.03,-3.32,;5.11,-1.83,)|

Structure