| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A2b |
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| Ligand | BDBM561394 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Adenosine A2B Receptor Cyclic AMP GS Assay |
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| EC50 | <10±n/a nM |
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| Citation |  Huang, T; Wang, X Pyrazolopyridines and triazolopyridines as A2A / A2B inhibitors US Patent US11390624 Publication Date 7/19/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A2b |
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| Name: | Adenosine receptor A2b |
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| Synonyms: | AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 36341.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 332 |
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| Sequence: | MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFA
IPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGT
RARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMS
YMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIV
GIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYT
FHKIISRYLLCQADVKSGNGQAGVQPALGVGL
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| BDBM561394 |
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| n/a |
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| Name | BDBM561394 |
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| Synonyms: | 3-(7-amino-2-(pyridin-2-ylmethyl)-4-(pyrimidin-4-yl)-2H-pyrazolo[3,4-c]pyridin-5-yl)benzonitrile | US11390624, Example 8 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H16N8 |
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| Mol. Mass. | 404.4267 |
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| SMILES | Nc1nc(-c2cccc(c2)C#N)c(-c2ccncn2)c2cn(Cc3ccccn3)nc12 |
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| Structure | 
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