Ki Summary

Reaction Details

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Target

Adenosine receptor A2b

Ligand

BDBM561411

Substrate/Competitor

n/a

Meas. Tech.

Adenosine A2B Receptor Cyclic AMP GS Assay

EC50

<10±n/a nM

Citation

Huang, T; Wang, X Pyrazolopyridines and triazolopyridines as A2A / A2B inhibitors US Patent US11390624 Publication Date 7/19/2022

More Info.:

Get all data from this article, Assay Method

Adenosine receptor A2b

Name:

Adenosine receptor A2b

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

36341.22

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

332

Sequence:

MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFA
IPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGT
RARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMS
YMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIV
GIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYT
FHKIISRYLLCQADVKSGNGQAGVQPALGVGL

BDBM561411

n/a

Name

BDBM561411

Synonyms:

3-(4-amino-2-((6-methylpyridin-2-yl)methyl)-7-(3-methylpyridin-4-yl)-2H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)benzonitrile | US11390624, Example 26

Type

Small organic molecule

Emp. Form.

C25H20N8

Mol. Mass.

432.4799

SMILES

Cc1cccc(Cn2nc3c(N)nc(-c4cccc(c4)C#N)c(-c4ccncc4C)c3n2)n1 |(8.93,1.13,;7.39,1.13,;6.62,2.46,;5.08,2.46,;4.31,1.13,;5.08,-.21,;4.31,-1.54,;2.77,-1.54,;1.87,-2.79,;.4,-2.31,;-.93,-3.08,;-.93,-4.62,;-2.26,-2.31,;-2.26,-.77,;-3.6,,;-3.6,1.54,;-4.93,2.31,;-6.27,1.54,;-6.27,,;-4.93,-.77,;-7.6,-.77,;-8.93,-1.54,;-.93,,;-.93,1.54,;-2.26,2.31,;-2.26,3.85,;-.93,4.62,;.4,3.85,;.4,2.31,;1.74,1.54,;.4,-.77,;1.87,-.29,;6.62,-.21,)|

Structure